CloneID: 11G5a
Antigen Long Description: This antibody was raised by immunizing mice.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P48509
Specificity Statement: This antibody binds to the CD151-integrin α3β1 binding site of the CD151 extracellular domain.
Application Notes (Clone): The antibody has been used in flow cytometry experiments and to assess the interaction of CD151 with integrins (Yauch 1998). CD151 can also regulate cell migration independent of integrins in cancer for tumour cell migration, and mAb 11G5a has been used for histologic detection of CD151 free in prostate cancer, which correlates with poor patient outcome (TD Palmer 2014).
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