Anti-CD70 (BU69)

Anti-CD70 (BU69), Recombinant, IgG1 kappa, Host: Mouse

CloneID: BU69

Antigen Long Description: Murine antibodies were produced by immunising BALB/c mice using the Waldenstrom's macroglobulinaemia cell line WM-1. Hybridomas were generated by fusion of immunised cells with the myeloma cell line P3/NS1/1-Ag4.1 via established methods.

Buffer Composition: PBS only.

Uniprot Accession No.: P32970

Specificity Statement: This antibody binds human CD70, which is the CD27 ligand. This protein is present only on activated dendritic cells and T lymphocytes, and represents a therapeutic target of relevance for autoimmune diseases.

Application Notes (Clone): BU69 has been used for FACS and immunocytochemistry analysis of the cell-surface expression levels of CD70 in renal cell carcinomas (Adam et al, 2006). It was shown in this study that cell-surface binding of BU69 to CD70 caused rapid internalisation of the cell-surface glycoprotein.

• Artikelnummer: ABAAb00818-1.1-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab00818-1.1-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Immunoprecipitation, Immunohistochemistry, Fluorescence-Activated Cell Sorting (FACS)
• Isotyp: IgG1 kappa
• Wirt: Mouse