CloneID: 14
Heavy Chain modification: Fc Silent™
Antigen Long Description: Murine antibodies were produced by immunising mice with human monocytes. Immunised cells were used to produce a hybridoma from which the antibodies were purified.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: Clone 14 binds human CD8, which is a coreceptor for the T lymphocyte receptor (TCR). CD8 binds, as a heterodimer, to class 1 MHC molecules and facilitates antigen-specific activation of the adaptive immune response. CD8 mutations are associated with various immunodeficiencies and pathologies.
Application Notes (Clone): Clone 14 has been used to investigate the cell type-dependent expression of CD8 in nephrectomised rats by IHC methods (Xiao et al, 2014), and can further be used for detection of T cell population subsets.
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