CloneID: RFF-VII/1
Antigen Long Description: This antibody was raised by immunising Balb/c mice with purified human factor VII.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P08709
Specificity Statement: This antibody is specific for human coagulation factor VII, a serine protease that initiates the extrinsic pathway of coagulation and circulates as a zymogen.
Application Notes (Clone): This antibody binds with high affinity to human factor VII, and acts as an inhibitor of factor VII coagulation activity (Takase et al, 1988).When coupled to sepharose, this antibody has been used to deplete factor VII from plasma (Sarial et al, 2012). The specificity of this antibody for factor VII has been confirmed in a double monoclonal immunoradiometric assay for factor VII antigen (Takase et al, 1988).
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