CloneID: 7E.17G9
Antigen Long Description: Rats were immunized i.m. three times with 500 mg murine ICOS cDNA in the pAXEF mammalian expression vector and boosted twice with 200 mg murine ICOS hexahistidine fusion protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This anitbody binds to mouse ICOS (CD278).
Application Notes (Clone): This antibody can be used to detect mouse ICOS by flow-cytometry. Maazi et al (2015, PMID: 25769613) showed that 7E.17G9 can inhibit ICOS interaction with its ligand ICOSL.
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