CloneID: RMP1-14
Heavy Chain modification: Bispecific antibody
Antigen Long Description: The original rat hybridoma was generated by immunizing Sprague Dawley rats with mouse PD-1-transfectked BHK cells. A P3U1 myeloma was used as the fusion partner.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a bispecific anti-mouse antibody created by fusing anti-PDL-1 VHH domains to the C-terminus of the heavy chains of the anti-mouse PD-1 antibody clone RMP1-14 in a mouse IgG1 D265A format. The mouse IgG1 D265A format is an Fc-silenced format, preve
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody binds to murine PD-1.
Application Notes (Clone): Binding of the original rat IgG2a antibody to PD1 has been reported to prevent binding of both B7-H1-Ig (PD-L1-Ig) and B7-DC-Ig (PD-L2-Ig) fusion proteins to PD1.
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