CloneID: JOVI.1
Heavy Chain modification: Fc Silent™
Antigen Long Description: Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody binds to human V-beta 3 chain of the T-cell receptor. In particular this antibody binds to the TRBC1 variant but not the TRBC2 variant.
Application Notes (Clone): This antibody can be used to detect the TCR beta chain in a majority (50-75%) of T-cell receptors by flow cytometry, immunofluorescence and can immunoprecipitate the TCR beta protein (variant 1). Recently it has been combined into a chimeric antigen antigen receptor therapy approach to selectively deplete a subset of T-cells in T-cell lymphomas or leukaemias, whilst leaving the non-reactive T-cell subset intact.
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