Anti-V(beta)3 TCR (JOVI.1)

Anti-V(beta)3 TCR (JOVI.1), Recombinant, IgG2a kappa, Host: Mouse

CloneID: JOVI.1

Heavy Chain modification: Fc Silent™

Antigen Long Description: Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.

Buffer Composition: PBS only.

Specificity Statement: This antibody binds to human V-beta 3 chain of the T-cell receptor. In particular this antibody binds to the TRBC1 variant but not the TRBC2 variant.

Application Notes (Clone): This antibody can be used to detect the TCR beta chain in a majority (50-75%) of T-cell receptors by flow cytometry, immunofluorescence and can immunoprecipitate the TCR beta protein (variant 1). Recently it has been combined into a chimeric antigen antigen receptor therapy approach to selectively deplete a subset of T-cells in T-cell lymphomas or leukaemias, whilst leaving the non-reactive T-cell subset intact.

• Artikelnummer: ABAAb00846-2.3-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab00846-2.3-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Immunofluorescence, Immunoprecipitation, Immunohistochemistry, Fluorescence-Activated Cell Sorting (FACS)
• Isotyp: IgG2a kappa
• Wirt: Mouse