Product Description: DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1].
Applications: Neuroscience-Neurodegeneration
Formula: C23H18N2O
References: [1]Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10(6):e0128308./[2]Hedrick E, et al. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Mol Cell Biol. 2016 Apr 15;36(9):1383-94.
CAS Number: 151358-47-3
Molecular Weight: 338.40
Compound Purity: 99.05
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Apoptosis;Nuclear Hormone Receptor 4A/NR4A
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