Apaf-1 Blocking Peptide

Apaf-1 Blocking Peptide
Artikelnummer
CAY360780
Verpackungseinheit
200 µg
Hersteller
Cayman Chemical

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Formulation: A lyophilized peptide

Shelf life (days): 1095

Notes: Each vial contains 200 µg of lyophilized peptide corresponding to amino acids 12 to 28 of human Apaf-1.{6894} Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf-1 (for apoptosis protease-activating factor 1).{6894,6873} Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.{6874} Apaf-1 can also associate with caspase-4 and caspase-8.{6878} Apaf-1 is ubiquitously expressed in human tissues.{6894}
Mehr Informationen
Artikelnummer CAY360780
Hersteller Cayman Chemical
Hersteller Artikelnummer 360780-200
Verpackungseinheit 200 µg
Mengeneinheit STK
Methode Western Blotting
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