MDL 800, CAS 2275619-53-7

MDL 800, CAS 2275619-53-7
Artikelnummer
CAY35528-10
Verpackungseinheit
10 mg
Hersteller
Cayman Chemical

Verfügbarkeit: wird geladen...
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Formulation: A solid

Formal Name: 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-benzoic acid, methyl ester

Purity: ≥98%

Formula Markup: C21H16BrCl2FN2O6S2

Formula Weight: 626,3

Shelf life (days): 1460

CAS Number: 2275619-53-7

Notes: MDL 800 is an allosteric activator of sirtuin 6 (SIRT6).{65174} It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50 = 23.3 µM) in, and reduces proliferation of, BEL-7405 hepatocellular carcinoma (HCC) cells (EC50 = 90.4 µM). MDL 800 (0.1-5 µM) inhibits TNF-α release induced by oxygen and glucose deprivation (OGD) in primary mouse microglia.{65173} In vivo, MDL 800 (50, 100, and 150 mg/kg) reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model.{65174}
Mehr Informationen
Artikelnummer CAY35528-10
Hersteller Cayman Chemical
Hersteller Artikelnummer 35528-10
Verpackungseinheit 10 mg
Mengeneinheit STK
Methode Reinstoffe
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