Product Description: Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect[1][2][3][4].
Applications: Cancer-Kinase/protease
Formula: C14H23Cl2N3O
Citations: Dev Cell. 2025 Jun 23;60(12):1751-1767.e9./ACS Appl Mater Interfaces. 2022 May 25;14(20):23219-23231./ACS Biomater Sci Eng. 2022 Mar 14;8(3):1301-1311./ACS Biomater Sci Eng. 2023 Feb 13;9(2):856-868./ACS Nano. 2025 Aug 19;19(32):29073-29086./ACS Omega. 2025 Apr 22;10(17):17228-17236./Acta Neuropathol Commun. 2024 Sep 14;12(1):150./Acta Neuropathol Commun. 2025 May 27;13(1):118./Acta Pharm Sin B. 2023 Jul;13(7):3027-3042./Adv Healthc Mater. 2021 May;10(10):e2002103./Adv Healthc Mater. 2025 Sep 18:e01846./Adv Mater Interfaces. 2024 Sep 03./Adv Mater. 2025 May 28:e2419768./Adv Redox Res. 2025 Sep./Adv Sci (Weinh). 2020 Jun 17;7(15):1903583./Adv Sci (Weinh). 2024 Feb;11(5):e2303088./Adv Sci (Weinh). 2024 May 20:e2307216./Adv Sci (Weinh). 2025 Apr 13:e2413376./Adv Ther. 2024 April 30./Adv Ther. 2024 Jul 18./Anal Chem. 2017 Oct 17;89(20):10841-10849./Ann Surg Oncol. 2024 Mar;31(3):1996-2007./Antioxid Redox Signal. 2025 Jul 25./Arch Oral Biol. 2025 Jan:169:106115./Autophagy. 2025 Jul 09./Bioact Mater. 2021 Jun 1:7:364-376./Bioact Mater. 2022 Aug 14:21:69-85./Bioact Mater. 2023 Mar 20:26:413-424./Bioact Mater. 2024 Jun 14:40:244-260./Biochem Biophys Rep. 2022 Jul 2:31:101299./Biochem Biophys Res Commun. 2019 Aug 20;516(2):571-577./Biochem Biophys Res Commun. 2019 Oct 29;519(1):134-140./Biochem Biophys Res Commun. 2023 Aug 6:668:8-18./Bioengineered. 2022 Apr;13(4):8747-8758./Bioengineering (Basel). 2020 Dec 18;7(4):164./Biol Reprod. 2025 May 13:ioaf108./Biology (Basel). 2023 Jun 20;12(6):888./Biomater Adv. 2024 Feb:157:213751./Biomater Adv. 2025 Apr 9:174:214316./Biomater Res. 2025 Oct 22./Biomaterials. 2020 May;240:119849./Biomaterials. 2020 Nov;258:120284./Biomaterials. 2024 Mar:305:122462./Biomed Pharmacother. 2022 Sep:153:113465./Biomed Pharmacother. 2025 Apr 3:186:118025./Biomed Res Int. 2021 May 14:2021:5565748./Biomedicines. 2024 Nov 27;12(12):2708./Biophys J. 2025 Sep 2;124(17):2840-2853./bioRxiv. 2020 Aug./bioRxiv. 2020 Mar./bioRxiv. 2023 Dec 6./bioRxiv. 2023 Feb 24:2023.02.24.529861./bioRxiv. 2023 Jul 1./bioRxiv. 2023 Jun 22./bioRxiv. 2023 Jun 28./bioRxiv. 2023 Mar 1./bioRxiv. 2024 Aug 12:2024.08.12.607571./bioRxiv. 2024 Feb 18./bioRxiv. 2024 Nov 15:2024.11.13.623500./bioRxiv. 2024 November 15./bioRxiv. 2024 November 26./bioRxiv. 2024 September 07./bioRxiv. 2025 April 03./bioRxiv. 2025 April 30./bioRxiv. 2025 Aug 09./bioRxiv. 2025 Feb 22:2025.02.17.638725./bioRxiv. 2025 January 15./bioRxiv. 2025 Jun 18./bioRxiv. 2025 March 25./bioRxiv. 2025 May 09./bioRxiv. 2025 Sep 8:2025.09.05.671511./bioRxiv. January 16, 2022./Biosci Biotechnol Biochem. 2021 Sep 22;85(10):2137-2144./BMC Cancer. 2023 Jun 22;23(1):577./BMC Pulm Med. 2023 Dec 13;23(1):505./BMC Urol. 2021 Jan 6;21(1):5./Bone Res. 2022 Jan 3;10(1):1./Br J Cancer. 2025 Aug 26./Brain Res. 2021 Dec 15:1773:147684./Can Respir J. 2022 Oct 10:2022:6879539./Cancer Cell Int. 2024 Jul 25;24(1):263./Cancer Cell. 2023 Jun 12;41(6):1103-1117.e12./Cancer Cell. 2024 Jun 10;42(6):1086-1105.e13./Cancer Lett. 2019 Apr 28:448:117-127./Cancer Med. 2024 Nov;13(21):e70397./Cancer Res. 2023 Feb 3;83(3):398-413./Cancer Res. 2025 Aug 29./Cancer Res. 2025 Oct 9./Cancers (Basel). 2021 Jun 30;13(13):3282./Cell Biochem Biophys. 2024 Mar;82(1):127-137./Cell Biol Toxicol. 2025 Aug 20;41(1):126./Cell Biosci. 2024 May 22;14(1):65./Cell Death Dis. 2022 Aug 24;13(8):730./Cell Death Dis. 2023 Apr 20;14(4):280./Cell Death Dis. 2024 Aug 3;15(8):559./Cell Death Dis. 2025 May 14;16(1):380./Cell Death Discov. 2023 Jan 25;9(1):32./Cell Discov. 2021 Apr 19;7(1):25./Cell Discov. 2022 Apr 19;8(1):35./Cell Genom. 2025 Jul 9;5(7):100881./Cell Mol Biol Lett. 2025 Jan 29;30(1):14./Cell Prolif. 2022 Apr;55(4):e13209./Cell Prolif. 2023 Jan;56(1):e13320./Cell Prolif. 2024 Jun;57(6):e13599./Cell Prolif. 2025 Jul 16:e70097./Cell Regen. 2020 Sep 3;9(1):15./Cell Rep Med. 2023 Feb 21;4(2):100911./Cell Rep Med. 2025 Feb 18;6(2):101966./Cell Rep Methods. 2024 Aug 27:100843./Cell Rep Methods. 2024 May 8:100777./Cell Rep Phys Sci. 2025 Oct 15;6(10)./Cell Rep. 2023 May 2;42(5):112445./Cell Rep. 2023 Oct 5;42(10):113213./Cell Rep. 2019 Jan 8;26(2):407-414.e5./Cell Res. 2023 Dec;33(12):904-922./Cell Signal. 2024 May 8:111223./Cell Signal. 2025 Nov:135:111981./Cell Stem Cell. 2020 Oct 1;27(4):646-662.e7. /Cell Stem Cell. 2022 Sep 1;29(9):1346-1365.e10./Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9./Cell. 2024 Jul 25;187(15):3936-3952.e19./Cells. 2023 Dec 30;13(1):81./Cells. 2024 Aug 31./Cells. 2024 Oct 14;13(20):1697./Chem Biol Interact. 2021 Oct 1:348:109625./Chem Eng J. 1 January 2023, 138737./Chem Eng J. 2024 Apr 1, 485, 149884./Circ Res. 2020 Oct 9;127(9):1182-1194./Clin Mol Hepatol. 2023 Apr;29(2):465-481./Compos B Eng. 2023 Apr 6, 110711./Connect Tissue Res. 2022 Sep;63(5):475-484./Curr Med Sci. 2024 Aug;44(4):718-725./Dev Cell. 2025 Jun 25:S1534-5807(25)00362-4./Device. 2024 June 12/EBioMedicine. 2024 Nov:109:105390./EJNMMI Res. 2024 Sep 27;14(1):86./EMBO Mol Med. 2023 Jan 11;15(1):e16373./Engineering. 2025 Aug 27./Engineering. 2025 Jul 30./Environ Int. 2025 Jan:195:109266./Environ Pollut. 2020 Jun;261:114153./Environ Toxicol Pharmacol. 2023 Nov:104:104301./Eur J Cell Biol. 2024 May 28;103(2):151427./Eur J Immunol. 2022 Aug;52(8):1308-1320./Eur J Pharmacol. 2025 Apr 11:177623./Exp Cell Res. 2025 Jun 2;450(2):114629./Exp Mol Med. 2021 Sep;53(9):1366-1378./Exp Mol Med. 2023 Jun;55(6):1258-1271./Exp Mol Med. 2025 Sep;57(9):1940-1950./Exp Ther Med. 2021 Apr;21(4):317./Extracell Vesicle. 2025 Jun./FASEB J. 2022 Nov;36(11):e22580./FEBS J. 2025 Apr;292(7):1696-1709./Food Chem Toxicol. 2024 Nov:193:115039./Food Funct. 2025 Aug 26;16(17):6786-6799./Front Cell Dev Biol. 2021 Jun 24:9:670825./Front Med. 2021 Sep 23;8:746298./Front Physiol. 2020 Jun 30;11:669./Fundam Res. 2025 Sep 24./Gut Microbes. 2022 Jan-Dec;14(1):2139978./Harvard Medical School LINCS LIBRARY/Hepatol Commun. 2025 Aug 15;9(9):e0778./Hum Cell. 2024 Nov 4;38(1):13./Hum Mol Genet. 2023 Jan 6;32(2):231-243./Immunity. 2022 Apr 12;55(4):686-700.e7./Immunity. 2025 Apr 8;58(4):946-960.e10./In Vitro Model. 2025 Mar 5;4(1):31-44./Int Endod J. 2025 Jun;58(6):873-889./Int Immunopharmacol. 2025 Apr 15:155:114657./Int Immunopharmacol. 2025 Jan 17:148:114068./Int J Biochem Cell Biol. 2025 Jun 9:186:106820./Int J Biol Sci. 2022 Aug 29;18(14):5459-5474./Int J Chron Obstruct Pulmon Dis. 2024 Jul 8:19:1591-1601./Int J Mol Med. 2024 Nov;54(5):99./Int J Mol Sci. 2022 Nov 24;23(23):14637./Int J Mol Sci. 2023 Oct 31;24(21):15804./Int J Mol Sci. 2024 Apr 9, 25(8), 4138./Int J Mol Sci. 2025 May 31;26(11):5306./Int J Stem Cells. 2023 May 30;16(2):156-167./Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):19./Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):61./iScience. 2021 Oct 19;24(11):103303./iScience. 2023 Aug 29;26(10):107773./J Biochem Mol Toxicol. 2025 Oct;39(10):e70500./J Biol Chem. 2023 Dec;299(12):105361./J Biol Chem. 2025 Jan 27:108235./J Biol Eng. 2024 Jan 16;18(1):7./J Biosci Bioeng. 2021 Apr;131(4):434-441./J Bone Oncol. 2021 Sep 20:30:100391./J Cancer Res Clin Oncol. 2024 Sep 19;150(9):424./J Cancer. 2025 Jun 9;16(8):2613-2625./J Cell Mol Med. 2020 Jul;24(14):8179-8193./J Cell Mol Med. 2025 Feb;29(4):e70423./J Clin Invest. 2022 Mar 1;132(5):e154993./J Clin Invest. 2025 Aug 12:e188839./J Clin Invest. 2025 Jun 2;135(11):e184158./J Clin Med. 2019 Oct 21;8(10):1751./J Immunother Cancer. 2024 Apr 19;12(4):e008628./J Immunother Cancer. 2025 Jan 7;13(1):e009356./J Med Chem. 2019 Jul 11;62(13):6083-6101./J Nanobiotechnology. 2025 Aug 21;23(1):579./J Neuroinflammation. 2024 Apr 10;21(1):88./J Neurosci. 2021 Jan 20;41(3):392-407./J Transl Med. 2023 Oct 10;21(1):711./J Virol. 2021 Feb 24;95(10):e02436-20./J Virol. 2023 May 31;97(5):e0177022./J Virol. 2025 Apr 15;99(4):e0176124./JCI Insight. 2024 Apr 23:e171916./Laryngoscope. 2025 Jun 7./Life Sci Alliance. 2025 Oct 13;9(1):e202403020./Life Sci. 2020 Apr 1;246:117419./Life. 2021 Aug 5;11(8):789./Mater Sci Eng C Mater Biol Appl. 2021 Mar:122:111939./Med Sci Monit. 2018 May 27:24:3514-3523./Methods Mol Biol. 2023:2683:53-68./Methods Mol Biol. 2024:2767:43-52./Methods Mol Biol. 2024:2767:53-62./Microsyst Nanoeng. 2024 Jul 15:10:97./Mol Cancer. 2024 Jan 10;23(1):12./Mol Cancer. 2024 Jun 8;23(1):125./Mol Cancer. 2025 Oct 2;24(1):238./Mol Cell. 2021 Jul 1;81(13):2736-2751.e8./Mol Hum Reprod. 2025 May 26:gaaf017./Mol Med. 2023 Oct 20;29(1):139./Mol Neurobiol. 2024 Oct;61(10):8402-8413./Nat Cancer. 2025 May;6(5):768-785./Nat Cell Biol. 2022 Jun;24(6):858-871./Nat Chem Biol. 2025 Oct 8./Nat Commun. 2022 Apr 19;13(1):2028./Nat Commun. 2022 Jun 1;13(1):3060./Nat Commun. 2022 Sep 6;13(1):5237./Nat Commun. 2023 Apr 6;14(1):1912./Nat Commun. 2023 Aug 8;14(1):4779./Nat Commun. 2024 Aug 5;15(1):6626./Nat Commun. 2024 Feb 19;15(1):1493./Nat Commun. 2024 Feb 7;15(1):1150./Nat Commun. 2024 Mar 11;15(1):2192./Nat Commun. 2024 May 30;15(1):4590./Nat Commun. 2025 Aug 5;16(1):7190./Nat Commun. 2025 Feb 26;16(1):1999./Nat Commun. 2025 Jul 1;16(1):6016./Nat Commun. 2025 Mar 17;16(1):2635./Nat Commun. 2025 Mar 26;16(1):2941./Nat Commun. 2025 Sep 29;16(1):8541./Nat Genet. 2024 Feb;56(2):294-305./Nat Genet. 2025 Feb;57(2):369-378./Nat Immunol. 2025 Oct;26(10):1660-1672./Nat Methods. 2025 Mar;22(3):510-519./Nat Photonics. 2025 Jul 10./Nature. 2025 Feb;638(8049):225-236./Nature. 2025 Nov;647(8088):257-267./Nature. 2025 Oct 22./Naturwissenschaften. 2025 Jul 23;112(4):53./Neurotherapeutics. 2021 Apr;18(2):1273-1294./NPJ Regen Med. 2022 Jun 16;7(1):31./Npj Viruses. 2024 Sep 2;2(1):42./Nutr
Deutsch
English
