Mouse anti ICAM-3

Mouse anti ICAM-3, Monoclonal, IgG1/k, Clone: JA4
Artikelnummer
NORMUB2039P
Verpackungseinheit
0,1 mg
Hersteller
Nordic-MUbio

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Clone: JA4

Background: Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a type I transmembrane glycoprotein, which normally contain 2-9 immunoglobulin-like C2-type domains, and binds to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 has previously been implicated in apoptotic cell clearance, although its precise role in the clearance process is ill defined.

Source: JA4 is a mouse monoclonal IgG1/k antibody derived by fusion of mouse Ag8.653 cells with spleen cells from a BALB/c mouse immunized with an ICAM-3/HEK transfectant.

Specificity: JA4 recognizes a linear epitope in domains 1 and 2 of ICAM-3.

Formulation: Each vial contains 100 µl 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

References: 1. Torr EE, Gardner DH, Thomas L, Goodall DM, Bielemeier A, Willetts R, Griffiths HR, Marshall LJ, Devitt A. Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells. Cell Death Differ. 2012;19: 671–679.

UniProt: P32942
Mehr Informationen
Artikelnummer NORMUB2039P
Hersteller Nordic-MUbio
Hersteller Artikelnummer MUB2039P
Verpackungseinheit 0,1 mg
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Immunohistochemistry (frozen), Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry
Isotyp IgG1/K
Human Gene ID JA4
Wirt Mouse
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