Product Description: Nitrofurazone (Standard) is the analytical standard of Nitrofurazone. This product is intended for research and analytical applications. Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria[1][2][3][4][5].
Formula: C6H6N4O4
References: [1]Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011;1:63./[2]McCalla DR, et al. Mode of action of nitrofurazone. J Bacteriol. 1970 Dec;104(3):1126-34./[3]Tu Y, et al. Effect of nitrofurazone on bacterial RNA and ribosome synthesis and on the function of ribosomes. Chem Biol Interact. 1976 Jul;14(1-2):81-91./[4]Z Kari FW, et al. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989 Feb;27(2):129-37./[5]Neal RA, et al. The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo. Ann Trop Med Parasitol. 1988 Oct;82(5):453-6./[6]Takahashi M, et al. Possible mechanisms underlying mammary carcinogenesis in female Wistar rats by nitrofurazone. Cancer Lett. 2000 Aug 11;156(2):177-84./[7]Hiraku Y, et al. Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation. Cancer Lett. 2004 Nov 25;215(2):141-50./[8]Nogueira Filho MA, et al. Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits. Drug Metab Lett. 2013 Mar;7(1):58-64.
CAS Number: 59-87-0
Molecular Weight: 198.14
Research Area: Infection
Target: Antibiotic;Bacterial;Reference Standards
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