Product Description: PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity[1][2].
Applications: Cancer-Kinase/protease
Formula: C32H34Cl2N4O4S
References: [1]Christensen JG, et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res. 2003 Nov 1;63(21):7345-55./[2]Ma PC. et al. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin Cancer Res. 2005 Mar 15;11(6):2312-9.
CAS Number: 477575-56-7
Molecular Weight: 641.61
Compound Purity: 99.86
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;c-Met/HGFR
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