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Protein Catagory: Transport/other Proteins
Typ: Human
CAS Number: 9007-41-4
Molecular Weight: 24,000 Da
Immunogen: No
Compound Purity: ≥95% by SDS-PAGE
Applications: In Vitro Diagnostics, Inflammation, Complement System, Cardiovascular Disease, Rheumatoid Arthritis, Cancer, Alzheimer's
References: N/A
Product Description: C-reactive protein (CRP), an acute-phase reactant, belongs to the pentraxin family characterized by calcium-dependent ligand binding. Each 24 kDa subunit contains a phosphocholine (PC)-binding site on its recognition face, enabling opsonization of pathogens and apoptotic cells via exposed PC moieties on bacterial membranes or oxidized low-density lipoprotein (OxLDL). CRP activates the classical complement pathway by binding C1q and Fcγ receptors, enhancing phagocytosis and inflammatory cytokine release. Under inflammatory conditions, pentameric CRP (pCRP) dissociates into pro-inflammatory monomers (mCRP) at sites of endothelial activation, amplifying leukocyte adhesion and vascular permeability. Clinically, CRP serves as a biomarker for systemic inflammation, with plasma levels rising from <5 mg/L in healthy individuals to >200 mg/L in severe sepsis or trauma. Elevated baseline high-sensitivity CRP (hs-CRP >3 mg/L) predicts cardiovascular events, correlating with atherosclerosis progression and endothelial dysfunction. In oncology, CRP >10 mg/dL portends poor prognosis in pancreatic cancer, reflecting tumor-associated inflammation. CRP also links metabolic dysregulation, with levels >2.9 mg/L increasing type 2 diabetes risk via IL-6-mediated insulin resistance6. Autoimmune disorders like rheumatoid arthritis show CRP elevation proportional to disease activity, while Alzheimer’s disease involves CRP binding amyloid-β plaques to modulate neuroinflammation.
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