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Application: Useful for cell-based TL1A binding assays.
Background: TL1A, also known as TNFSF15 (tumor necrosis factor superfamily member 15) or VEGI (Vascular endothelial growth inhibitor), is a member of the tumor necrosis factor family. It is expressed in different immune cells, such as monocytes, macrophages, dendritic cells, T cells, and non-immune cells. TL1A competitively binds to DR3 (death receptor 3), having a higher affinity for DcR3 (decoy receptor 3), pand regulates proliferation, activation, apoptosis, and chemokine production in effector cells. The role of DR3 in T cell activation, and consequently in cytokine secretion and cell proliferation, makes it an attractive target in cancer therapy. Inhibition of DR3-TL1A interaction has substantial therapeutic potential in the treatment of solid tumors.
Description: TL1A CHO Cell Line is a clonal CHO cell line expressing full-length human TL1A (TNF-like ligand 1A) (NM_005118.4). The expressed TL1A may be released as a soluble form by proteolytic cleavage. This cell line has been validated by flow cytometry, and in a co-culture assay with TL1A-Responsive Luciferase Reporter Jurkat Cell line (#78811) in the presence of a TL1A neutralizing antibody.
Genbank: NM_005118.4
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains ˃1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Target: TL1A
Uniprot: O95150
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
References: Xu W. D., et al., 2022 Front. Immunol. 13: 1-10. Zwolak A., et al., 2022 Sci. Rep. 12(1): 20538.
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