Product Description: Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
Applications: Cancer-Kinase/protease
Formula: C15H10O5
References: [1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74(2):92-101./[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161(1):113-26./[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93(2-3):159-68.
CAS Number: 518-82-1
Molecular Weight: 270.24
Compound Purity: 99.39
Research Area: Cancer
Solubility: Acetone : 10.87 mg/mL (ultrasonic)/DMSO : 5.41 mg/mL (ultrasonic)/Ethanol : < 1 mg/mL (ultrasonic)
Target: 11β-HSD;Autophagy;Casein Kinase;SARS-CoV
English
Deutsch
