Product Description: Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C15H21N3O2S
References: [1]Tsorin IB, et al. Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. Bull Exp Biol Med. 2019 Sep;167(5):634-636. /[2]Pérez-Villanueva J, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110. /[3]Chernykh I V, et al. Study of fabomotizole belonging to p-glycoprotein substrates[J]. IP Pavlov Russian Medical Biological Herald, 2017, 25(4): 538-550./[4]Voronin MV, Vakhitova YV, Tsypysheva IP, Tsypyshev DO, Rybina IV, Kurbanov RD, Abramova EV, Seredenin SB. Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole. Int J Mol Sci. 2021 May 21;22(11):5455.
CAS Number: 173352-21-1
Molecular Weight: 307.41
Compound Purity: 99.96
Research Area: Infection; Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Monoamine Oxidase;Parasite;P-glycoprotein;Sigma Receptor
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