Methazolamide-d6, CAS 1795142-30-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide-d6

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C5H2D6N4O3S2

Formula Weight: 242.31054

CAS Number: 1795142-30-1

Notes: Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide (Item No. 23413) by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM).{36164} It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg.{36165} It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH.{36166} Formulations containing methazolamide have been used in the treatment of glaucoma.

• SKU: CAY33933-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33933-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung