Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L- isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3- mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L- methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto- D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl- L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl- L-lysine, cyclic (3?7),(8?11),(13?19),(23?26),(25?28)-pentakis(sulfide)
Formula Markup: C143H230N42O37S7
Formula Weight: 3354.1
CAS Number: 1414-45-5
Notes: Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide.{27112} It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.{27113} Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative.{27112,27114} Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.{27112,27114}
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