Protein Catagory: Immuneglobulins
Typ: Human
Molecular Weight: 50,000 Da
Immunogen: Yes
Compound Purity: 99% by SDS-PAGE; Single arc by IEP; Immunogen Grade per Western Blot
Applications: Flow Cytometry, ELISA, Antisera Production, In Vitro Diagnostics, Proteomics
References: N/A
Product Description: The Fc (fragment crystallizable) region of immunoglobulin G, while not binding antigen, contains crucial biological activities and antigenic determinants. This homodimeric glycoprotein comprises CH2 and CH3 domains and mediates immune effector functions through interactions with Fc receptors, C1q, and FcRn. Fc fragments orchestrate antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis while controlling IgG's serum half-life via pH-dependent FcRn binding. The conserved N-linked glycosylation at Asn-297 is essential for structural stability and receptor interactions. Altered Fc glycosylation patterns correlate with autoimmune conditions including rheumatoid arthritis, where reduced galactosylation and sialylation indicate inflammatory disease states. Fc receptor polymorphisms are also associated with autoimmune disease development.
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