Ponatinib

Key Reference: 1)O’Hare et al. (2009), AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance; Cancer Cell, 16 4012)Gozgit et al. (2011), Potent activity of ponatinib (AP24535) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies; Mol. Cancer Ther., 10 10283)Gozgit et al. (2012), Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models; Mol. Cance Ther., 11 6904)Chen et al. (2019), Ponatinib Protects Mice From Lethal Influenza Infection by Supressing Cytokine Storm; Front. Immunol., 10 1393.

Molecular Weight: 532.56 g/mol.

Product Format: Powder.

Purity: > 98%.

• SKU: AVIOOMC00087-25
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: OOMC00087-25
• Package Unit: 25 mg
• Quantity Unit: STK