Exosomes

Exosomes have recently became one of the hottest topics in biomedical research. Since 2013 when The Nobel Prize in Physiology or Medicine was awarded to James E. Rothman, Randy W. Schekman and Thomas C. Südhof for their discoveries of machinery regulating vesicle traffic, many research groups have begun to focus on exosomes as a crucial communication and transport tool between the cells in living organisms. Exosomes are supposed to play an active role in cancer spread (Iero M, 2008, Tumour-released exosomes and their implications in cancer immunity) as well as possibly serving as drug delivery vehicles (Kasper Bendix Johnsen, 2014, A comprehensive overview of exosomes as drug delivery vehicles – endogenous nanocarriers for targeted cancer therapy).

For this exciting area of research we offer the following products:

ExoStep™ from Immunostep – Immunobead assay kits for detection and isolation of exosomes for flow cytometry. We offer kits with or without exosome standard, to be used for exosome detection in cell culture supernatant, plasma and urine samples. The kits are available with CD63 capture and CD9 or CD81 exosome marker antibodies.

Single antibodies or antibodies conjugated to magnetic beads, fluorophores or biotin for exosome research – CD9, CD81, CD63, CD326, CD274

Exosome Standards and fluorescent exosome standards isolated from the following cultured cell lines from Abnova – SK-N-SH, HCT116, PC3, BPH-1, U87 MG, COLO1, MM1, BLCL21, DAU1, A549, K562, B16F10.