Target: Alpha Synuclein Oligomer ELISA Kit
Product Type: ELISA Kits
Scientific Background: Alpha synuclein oligomers represent a soluble, neurotoxic form of the presynaptic protein and are increasingly recognized as early drivers of pathology in neurodegenerative disease. These oligomeric species disrupt synaptic vesicle trafficking and neurotransmission, impairing presynaptic function well before the formation of mature fibrillar aggregates. Localized effects extend to mitochondria, where oligomers induce oxidative stress, lysosomal dysfunction, and endoplasmic reticulum stress, contributing to neuronal vulnerability in Parkinson’s disease (PD) and related synucleinopathies. Their capacity to propagate in a prion like manner and initiate early synaptic and inflammatory disturbances underscores their importance in disease progression and positions them as high value targets for biomarker development and therapeutic intervention. StressMarq’s Alpha Synuclein Oligomer ELISA has demonstrated higher affinity to oligomers than to PFFs or monomers.
References: 1.Ghiglieri, V., Calabrese, V., & Calabresi, P. (2018). Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration. Frontiers in neurology, 9, 295. https://doi.org/10.3389/fneur.2018.00295 2.Pitton Rissardo, J., McGarry, A., Shi, Y., Fornari Caprara, A. L., & Kannarkat, G. T. (2025). Alpha-Synuclein Neurobiology in Parkinson’s Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives. Brain Sciences, 15(12), 1260. https://doi.org/10.3390/brainsci15121260 3.Carvalho, R. (2025). Alpha Synuclein: A key player in neurodegenerative disorders. Journal of Neuroinfectious Diseases, 16(1). https://www.omicsonline.org/open-access-pdfs/alphasynuclein-a-key-player-in-neurodegenerative-disorders.pdf
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Detection Method: Colorimetric Assay
Assay Type: Sandwich ELISA
Utility: ELISA kit used to detect/quantitate the presence of alpha synuclein oligomers
Sample Type(s): Brain homogenate
Number of Samples: 40 samples in duplicate
Incubation Time: 3 hours
Sensitivity: 10 pg/mL
Assay Range: 15.6 – 1,000 pg/mL
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