15-hydroxy Prostaglandin Dehydrogenase Inhibitor Screening Kit

Shelf life (days): 180

Notes: Cayman’s 15-PGDH Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human 15-PGDH, the enzyme that catalyzes the oxidation of prostaglandins to 15-keto metabolites with reduced biological activity. Measurement of 15-PGDH activity is carried out by monitoring the reduction of NAD+ to NADH. The reduction of NAD+ to NADH is accompanied by an increase in fluorescence at 445 nm following excitation at 340 nm. The potent and reversible 15-PGDH inhibitor ML-148 Assay Reagent is included as a positive control and inhibits 15-PGDH with an IC50 value of 11 nM.

• SKU: CAY702180-384
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 702180-384
• Package Unit: 384 wells
• Quantity Unit: STK