Product Description: Interleukin-17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17BR receptor to stimulate the secretion of the proinflammatory Interleukin-8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).
Source: E. coli
Purity: >95% determined by reducing and non-reducing SDS-PAGE
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Endotoxin Level: <1.00 EU/ug as measured by kinetic LAL
Molecular Weight: 17.6 / 35.2 kDa
Stability and Storage: 12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Species: Mouse
Activity Assay: Mouse IL-17E is fully biologically active when compared to standard. The activity is determined by the ability to produce human IL-8 by human PBMC cells.
AA Sequence: MVSLRIQEGC SHLPSCCPSK EQEPPEEWLK WSSASVSPPE PLSHTHHAES CRASKDGPLN SRAISPWSYE LDRDLNRVPQ DLYHARCLCP HCVSLQTGSH MDPLGNSVPL YHNQTVFYRR PCHGEEGTHR RYCLERRLYR VSLACVCVRP RVMAA
Length: 154 / 308 aa
Structure: Dimer
Accession Number: Q8VHC9
Reconstitution: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
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