Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (S)-2-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)-L-alanyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C27H29D5N2O7
Formula Weight: 503.59844
CAS Number: 1356929-49-1
Notes: Moexipril-d5 intended for use as an internal standard for the quantification of moexipril (Item No. 21255) by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat.{33383} It is converted to moexiprilat in vivo by side chain ester hydrolysis.{33382} Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively).{33382} Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{33383} It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.{61337}
English
Deutsch
