Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(4-nitro-2-(phenoxy-d5)phenyl)methanesulfonamide
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C13H7D5N2O5S
Formula Weight: 313.34116
CAS Number: 1330180-22-7
Notes: Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide (Item No. 70640) by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively).{1364,1286} It is selective for COX-2 over COX-1 (IC50s = 70 and 22 µM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 µM for the rat kidney transporter.{58421} It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; Item No. 14010) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats.{5796} Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.{58422}
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