Human Prorenin, Native

Human Prorenin, Native, 0,1 mg
Artikelnummer
MOIHPREN-0,1
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Molecular Weight: 43725
Storage Buffer: 0.05M Tris-HCl; 0.05M NaCl; pH 8.0
Source: Human Embryonic Kidney cells
Extinction coefficient: 1,1
Purity: >95% by SDS-PAGE analysis
Gene: REN
Swiss ID: P00797
Description:

Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2).

1) A.H. Jan Danser; Jaap Deinum ; Renin, Prorenin and the Putative (Pro)renin Receptor). Hypertension. 2005;46:1069.

2) Luetscher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M.Increased plasma inactive renin in diabetes mellitus. A marker of microvascularcomplications. N Engl J Med. 1985;312:1412-1417.

Mehr Informationen
Artikelnummer MOIHPREN-0,1
Hersteller Molecular Innovations
Hersteller Artikelnummer HPREN-0,1
Verpackungseinheit 0,1 mg
Mengeneinheit FL
Reaktvität Human
Human Gene ID 5972
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