Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A(PRKRA)

Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A(PRKRA)
Artikelnummer
CSB-EP644142BO-1
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Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. MW: 39.4 kDa. Function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). Subcellular Location: Cytoplasm, perinuclear region, Cytoplasm. Protein Families: PRKRA family.
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Artikelnummer CSB-EP644142BO-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-EP644142BO-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktvität Cow (Bovine)
Wirt Escherichia Coli
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