Recombinant Human Centromere protein F(CENPF),partial

Recombinant Human Centromere protein F(CENPF),partial
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CSB-BP005210HU-1
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Organism: Homo sapiens (Human). Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. Involvement in disease: Stromme syndrome (STROMS). Subcellular Location: Cytoplasm, perinuclear region, Nucleus matrix, Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, spindle. Protein Families: Centromere protein F family. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged
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Artikelnummer CSB-BP005210HU-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-BP005210HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Methode Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
Wirt Various hosts
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