Tag Info: N-terminal 6xHis-tagged. MW: 36.0 kDa. Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Involvement in disease: Plasminogen deficiency (PLGD) . Subcellular Location: Secreted.Protein Families: Peptidase S1 family, Plasminogen subfamily.Tissue Specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.