Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. MW: 50.5 kDa. Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Involvement in disease: Pulmonary hypertension, primary, 4 (PPH4) . Subcellular Location: Cell membrane, Multi-pass membrane protein.Protein Families: Two pore domain potassium channel (TC 1.A.1.8) family.Tissue Specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.