Species: Homo sapiens (Human). Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members. Involvement in disease: Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3). Subcellular Location: Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus. Protein Families: Peptidase S8 family. Tissue Specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. Tag Info: C-terminal Avi-tagged.