Recombinant Human Serine/threonine-protein kinase N1(PKN1),partial

Recombinant Human Serine/threonine-protein kinase N1(PKN1),partial
Artikelnummer
CSB-EP623082HU-1
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Organism: Homo sapiens (Human). Function: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. Subcellular Location: Cytoplasm, Nucleus, Endosome, Cell membrane, Peripheral membrane protein, Cleavage furrow, Midbody. Protein Families: Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily. Tissue Specificity: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. Tag Info: N-terminal 6xHis-tagged
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Artikelnummer CSB-EP623082HU-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-EP623082HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktvität Human
Wirt Escherichia Coli
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