Recombinant Human SH3 and PX domain-containing protein 2A(SH3PXD2A),partial

Recombinant Human SH3 and PX domain-containing protein 2A(SH3PXD2A),partial
Artikelnummer
CSB-EP735983HU-1
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Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. MW: 14.0 kDa. Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Subcellular Location: Cytoplasm, Cell projection, podosome. Protein Families: SH3PXD2 family. Tissue Specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
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Artikelnummer CSB-EP735983HU-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-EP735983HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktvität Human
Methode Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
Wirt Escherichia Coli
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