Recombinant Human Single-stranded DNA cytosine deaminase(AICDA)

Recombinant Human Single-stranded DNA cytosine deaminase(AICDA)
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Organism: Homo sapiens (Human). Function: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. Involvement in disease: Immunodeficiency with hyper-IgM 2 (HIGM2). Subcellular Location: Nucleus, Cytoplasm. Protein Families: Cytidine and deoxycytidylate deaminase family. Tissue Specificity: Strongly expressed in lymph nodes and tonsils. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged
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Artikelnummer CSB-BP001487HU-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-BP001487HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Wirt Various hosts