Recombinant Human Three-prime repair exonuclease 1(TREX1)

Recombinant Human Three-prime repair exonuclease 1(TREX1)
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Organism: Homo sapiens (Human). Function: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Involvement in disease: Aicardi-Goutieres syndrome 1 (AGS1); Systemic lupus erythematosus (SLE); Chilblain lupus 1 (CHBL1); Vasculopathy, retinal, with cerebral leukodystrophy (RVCL). Subcellular Location: Nucleus, Cytoplasm, cytosol, Endoplasmic reticulum membrane, Peripheral membrane protein. Protein Families: Exonuclease superfamily, TREX family. Tissue Specificity: Detected in thymus, spleen, liver, brain, heart, small intestine and colon. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged
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Artikelnummer CSB-BP865133HU-1
Hersteller Cusabio
Hersteller Artikelnummer CSB-BP865133HU-1
Verpackungseinheit 1 mg
Mengeneinheit FL
Reaktvität Human
Methode Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
Wirt Various hosts