Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. MW: 60.0 kDa. Function: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Involvement in disease: Neuronopathy, distal hereditary motor, 9 (HMN9) . Subcellular Location: Cytoplasm.Protein Families: Class-I aminoacyl-tRNA synthetase family.