Recombinant Human Tumor necrosis factor receptor superfamily member 6(FAS)

Recombinant Human Tumor necrosis factor receptor superfamily member 6(FAS)
Artikelnummer
CSB-CF008433HU(A4)-10
Verfügbarkeit: wird geladen...
Preis wird geladen...
Organism: Homo sapiens (Human). Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Involvement in disease: Autoimmune lymphoproliferative syndrome 1A (ALPS1A). Subcellular Location: Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted. Tissue Specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. Tag Info: N-terminal 10xHis-tagged
Mehr Informationen
Artikelnummer CSB-CF008433HU(A4)-10
Hersteller Cusabio
Hersteller Artikelnummer CSB-CF008433HU(A4)-10
Verpackungseinheit 10 µg
Mengeneinheit FL
Methode Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
Wirt Escherichia Coli
Datenblatt
×
MSDS
×