Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. MW: 23.9 kDa. Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Subcellular Location: Secreted, Secreted, extracellular space, extracellular matrix. Tissue Specificity: Plasma. Expressed in liver.