Bulk anti-Human CD119 antibody (GIR 208)

Bulk anti-Human CD119 antibody (GIR 208), Host: Mouse, Mouse IgG1
Artikelnummer
ICH1028UL-5MG
Verpackungseinheit
5mg
Hersteller
Ichorbio

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Target: CD119.

Clone: GIR 208.

Specificity: Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha.

Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution: The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.

Background: Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.

Immunogen: Human IFN-gamma R alpha, Purified from human placenta.

Concentration: 1.0 - 5.0 mg/ml.

Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.

Purity: >98% by SDS-PAGE and HPLC.

Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method.

Aggregation: Aggregation level ≤ 1%.

Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Mehr Informationen
Artikelnummer ICH1028UL-5MG
Hersteller Ichorbio
Hersteller Artikelnummer ICH1028UL-5MG
Verpackungseinheit 5mg
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Immunoprecipitation, Western Blotting, Blocking, Functional Assay
Isotyp Mouse IgG1
Wirt Mouse
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