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Anti-Human CD38 In Vivo Antibody - Ultra Low Endotoxin (OKT10)

Anti-Human CD38 In Vivo Antibody - Ultra Low Endotoxin (OKT10)
1.141,61 €
Artikelnummer: ICH1157UL-25MG

Verfügbarkeit: Lieferzeit auf Anfrage

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Anti-Human CD38 In Vivo Antibody - Ultra Low Endotoxin (OKT10), Host: Mouse, IgG1

Details

Clone: OKT10.
Target: CD38.
Specificity: Clone OKT10 recognizes an epitope on human CD38.
Purification Method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CD38 is present on the surface of immune cells such as CD4+, CD8+, B lymphocytes, natural killer cells, mature lymphocytes, and mature lymphoplasmacytic cells.

Background: CD38 is a 45kD type II transmembrane glycoprotein that plays a role in the regulation of intracellular Ca2+ by synthesizing and hydrolyzing an intracellular calcium ion mobilizing messenger. CD38 has both extracellular and intracellular functions as indicated by the release of soluble protein and the ability of membrane-bound protein to become internalized. The functional molecule is a dimer that contains the catalytic site in the central portion, and is involved in both extracellular and intracellular functions. CD38 plays a role in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a biomarker to measure the progress of a chronic lymphocytic leukemia in patients. Because CD38 is expressed on mature lymphocytes and lymphoplasmacytic cells, OKT10 can be used to study final B cell maturation. OKT10 reactivity with CD38 occurs in an inversely proportional relationship to the occurrence of Ia-like antigenic expression. Hence, these two antigens can be used as reciprocal complementary reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenström malignancy.

Purity: >98% by SDS-PAGE and HPLC.
Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method.

Zusatzinformation

Artikelnummer ICH1157UL-25MG
Hersteller Ichorbio
Herstellernummer ICH1157UL-25MG
Verpackungseinheit 25 mg
Mengeneinheit FL
Reaktivität Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Flow Cytometry
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Auf Anfrage