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Anti-Human CD40 In Vivo Antibody - Ultra Low Endotoxin (G28.5)

Anti-Human CD40 In Vivo Antibody - Ultra Low Endotoxin (G28.5)
1.141,61 €
Artikelnummer: ICH1156UL-25MG

Verfügbarkeit: Lieferzeit auf Anfrage

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Anti-Human CD40 In Vivo Antibody - Ultra Low Endotoxin (G28.5), Host: Mouse, IgG1

Details

Clone: G28.5.
Target: CD40.
Specificity: Clone G28.5 recognizes an epitope on human CD40.
Purification Method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CD40 is widely expressed on antigen-presenting cells such as dendritic cells, B cells, macrophages, and monocytes, in addition to non-immune endothelial cells, basal epithelial cells, and a variety of tumors.

Background: CD40 is a 48 kD type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40, in association with its ligand CD154 (CD40L) - a 39 kD protein, acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other antigen presenting cells. CD40 is involved in Ig isotype switching and dendritic cell maturation, as well as the activation, differentiation and proliferation of B cells. CD40 interacts with TNFR2 and is involved in the regulation of signal transduction. CD40 is a potential target for cancer immunotherapy. Blocking the interaction of CD40 with its ligand (CD154) is the sought-after therapeutic objective for preventing and/or improving both autoimmune diseases and transplant rejection. Studies have shown that monoclonal antibodies that block CD154 in human clinical trials resulted in unanticipated vascular complications. Hence, an interest in the therapeutic potential for antagonist mAbs specific for human CD40 is emerging. Antibodies of particular therapeutic interest are those that do not inhibit CD40 signaling via physical competition with CD154. Additionally, the interaction of CD40 and its ligand (CD154) is found to be essential for amyloid-beta-induced microglial activation, thus plays a significant part in Alzheimer disease pathogenesis.

Purity: >98% by SDS-PAGE and HPLC.
Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method.

Zusatzinformation

Artikelnummer ICH1156UL-25MG
Hersteller Ichorbio
Herstellernummer ICH1156UL-25MG
Verpackungseinheit 25 mg
Mengeneinheit FL
Reaktivität Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Flow Cytometry, Functional Assay
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Auf Anfrage