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Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (2D5-1.9)

Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (2D5-1.9)
2.246,15 €
Artikelnummer: ICH1160-100MG

Verfügbarkeit: Lieferzeit auf Anfrage

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Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (2D5-1.9), Host: Mouse, IgG2a

Details

Clone: 2D5-1.9.
Target: Hepsin.
Specificity: Clone 2D5 recognizes Human hepsin. It binds to a separate epitope than clone 3H10.1. These clones do not interfere with one another.
Immunogen: Human hepsin protein.
Purification Method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: Hepsin is expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues.

Background: Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.5

Purity: >95% by SDS-PAGE and HPLC.
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method.

Zusatzinformation

Artikelnummer ICH1160-100MG
Hersteller Ichorbio
Herstellernummer ICH1160-100MG
Verpackungseinheit 100 mg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Flow Cytometry, Western Blotting
Isotype IgG2a
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Auf Anfrage