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Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (3H10.1)

Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (3H10.1)
899,30 €
Artikelnummer: ICH1161-25MG

Verfügbarkeit: Lieferzeit auf Anfrage

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Anti-Mouse Hepsin In Vivo Antibody - Low Endotoxin (3H10.1), Host: Mouse, IgG1

Details

Clone: 3H10.1.
Target: Hepsin.
Specificity: Clone 3H10.1.2 is able to recognize full-length native Hepsin expressed on the cell surface in addition to the recombinant soluble form. Clones 3H1.1.1 and 1F2.1.1 bind to the same epitope as clone 3H10.1.2 and inhibit it (and each other) from binding Hepsin. Clone 3H10.1.2 and clone 2D5.1.9 bind separate epitopes and do not inhibit each other from binding Hepsin.
Immunogen: Human hepsin protein.
Purification Method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: Hepsin is expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues.

Background: Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.3

Purity: >95% by SDS-PAGE and HPLC.
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method.

Zusatzinformation

Artikelnummer ICH1161-25MG
Hersteller Ichorbio
Herstellernummer ICH1161-25MG
Verpackungseinheit 25 mg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Auf Anfrage