CD45 antibody (MEM-28) (PE-DyLight 594)

Clone Name: MEM-28

Application Note: FACS: 4 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 147

Specificity/Sensitivity: This antibody reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen).,We do not recommend use of this product for Horse.

Form: Liquid

Buffer (with preservative): PBS, 15mM Sodium azide.

Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Uniprot ID: P08575

Antigen Species: Human

Immunogen: Human thymocytes and T lymphocytes.

Purification: Purified by size-exclusion chromatography

Conjugation: PE-DyLight 594

Full Name: protein tyrosine phosphatase receptor type C