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KDEL Receptor Antibody: APC/Cy7, Monoclonal

KDEL Receptor Antibody: APC/Cy7, Monoclonal
424,24 €
Artikelnummer: STRSMC-129D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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KDEL Receptor Antibody: APC/Cy7, Monoclonal, Clone: KR-10, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1
Target: KDEL Receptor
Purification: Protein G Purified
Specificity: Detects ~25kDa.
Conjugate: APC/Cy7
Immunogen Species: Bovine
Cellular Location: Endoplasmic Reticulum
Immunogen: A 21 residue synthetic peptide (amino acids 192-212) based on the bovine KDEL receptor and the peptide coupled to KLH
Scientific Background: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity; and all are located within the cis-Golgi and its intermediate compartments (4).In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).
Reference: 1. Whiteman P., and Handford P.A. (2003) Hum Mol Genet 12(7): 727-737. 2. Forthoffer N., et al. (2002) J Bioenerg Biomemb 34(3): 209-219. 3. Aoe T., et al. (1997) EMBO J. 16: 7305-7316. 4. Tang B.L., Wong S.H, Qi X.L. Low S.H., and Hong W. (1993) J. Cell Biol. 120: 325-328. 5. Lewis M.J. and Pelham H.R. (1990) Nature 348: 162-163. 6. Spurger L. (2002). Endoplasmic reticulum: Structure and function. University of Texas Medical Branch. Retrieved September 13, 2006, from http://cellbio.utmb.edu/cellbio/rer1.htm

Zusatzinformation

Artikelnummer STRSMC-129D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-129D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Chicken, Cow (Bovine), Dog (Canine), Frog (Xenopus Laevis), Fruit Fly (Drosophila Melanogaster), Hamster, Human, Monkey (Primate), Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download