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Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1 Dylight 594

Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1 Dylight 594
326,67 €
Artikelnummer: STRSMC-129D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1 Dylight 594, Clone: KR-10

Details

The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity; and all are located within the cis-Golgi and its intermediate compartments (4).In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).

1 µg/ml was sufficient for detection of KDEL receptor in 20 µg monkey Vero cell lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:AP as the secondary.

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Zusatzinformation

Artikelnummer STRSMC-129D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-129D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Chicken, Cow (Bovine), Dog (Canine), Frog (Xenopus Laevis), Fruit Fly (Drosophila Melanogaster), Hamster, Human, Monkey (Primate), Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download